The Silence of the Lambs

In the 1991 psychological thriller The Silence of the Lambs, Clarice Starling approaches the cell of Hannibal Lecter for her first meeting with the infamous killer. Passing other cells before reaching Lecter, Starling is harrassed by a few inmates including one played by the Neighborhood's Don Brockett.

Later in the film, we meet FBI Agent Terry -- played by another Neighborhood regular, Chuck Aber

One final Neighborhood connection comes as Hannibal Lecter escapes from his heavily guarded cell in Memphis. Playing the part of one of the responding officers is David Early. Mr. Early appeared as a teacher in Episode 1462 of Mister Rogers' Neighborhood.